Peptide ChooserPalmitoyl pentapeptide-4 (Matrixyl)
CosmeticChecked 30 Oct 2026
Cosmetic: cosmetics are regulated but do not need FDA approval to be sold. FDA source, 30 Oct 2026. Our skin page lists it. The lowest price at the 5 shops shown below is $0.14/mg (Ion Peptide), checked 18 Oct 2026.
Evidence by goal
What each goal page that lists it says, word for word, with its sources. The evidence rating comes from a goal page's checked options table; a goal without one shows "Not rated".
| Goal | Evidence in people | What the goal page says |
|---|---|---|
| SkinPalmitoyl pentapeptide-4 (Matrixyl) | Not rated | The most common "anti-wrinkle peptide" in creams. Modest effect in small studies. |
Where it is sold
The 5 shops in the price window on our goal pages, each with its cheapest listing by price per mg, most checks first. Research-use sellers; we do not link to them. Prices checked 23 Oct 2026.
| Shop | Size | Price | Per mg | Checks |
|---|---|---|---|---|
| Umbrella Labs | 200 mg | $75.99 | $0.38/mg | 3 of 5 checksLab reports: yesNo FDA letter: yesCompany found: noLegal pages: noFresh prices: yes |
| Core Peptides | 200 mg | $171.00 | $0.85/mg | 3 of 5 checksLab reports: yesNo FDA letter: yesCompany found: noLegal pages: noFresh prices: yes |
| Verified Peptides | 200 mg | $99.00 | $0.49/mg | 3 of 5 checksLab reports: yesNo FDA letter: yesCompany found: noLegal pages: noFresh prices: yes |
| Ion Peptide | 1000 mg | $139.00 | $0.14/mg | 3 of 5 checksLab reports: yesNo FDA letter: yesCompany found: noLegal pages: noFresh prices: yes |
| Peptide Warehouse | unknown | $36.99 | unknown | 1 of 5 checksLab reports: noNo FDA letter: yesCompany found: noLegal pages: noFresh prices: no |
Price per mg is the price divided by the stated amount. Checks are facts we hold about the seller, not a safety or quality grade. How we rate
FDA warning letters
Our letters list is by company, not by substance. The letters page lists all 172, each with its subject and a link to fda.gov; filter it by a company name.
Compared with: Acetyl hexapeptide-8 vs Palmitoyl pentapeptide-4
Sources
- FDA, status of Palmitoyl pentapeptide-4, 30 Oct 2026: https://www.fda.gov/cosmetics/laws-regulations/fda-authority-over-cosmetics-how-cosmetics-are-not-fda-approved-are-fda-regulated