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Peptides for weight loss, compared with the approved shots.

Peptide Chooser editorial team. Last updated 30 Oct 2026. Every claim links to its source. Prices checked 2 Nov 2026.

Two weekly shots are FDA approved for weight management, semaglutide (Wegovy) and tirzepatide (Zepbound), both on prescription. Online clinics also sell compounded copies, cheaper and not checked by the FDA batch by batch. Retatrutide is still in trials and sold only by research-use shops. Below: what each option costs at the clinics we track, and which clinics have an FDA warning letter.

Cheapest clinic plan, per month

$60 /mo from13

Compounded Semaglutide, Mochi Health
Checked 2 Nov 2026Compounded, not FDA approved, care fee not known. Not a prescription.

Compare the options

Is it legal today?

For losing weight with medical help: the two approved weekly shots, what they cost, and the copies sold online.

  • Semaglutide (Wegovy)FDA approved

    A weekly shot that cuts appetite; about 15 % body weight lost on average in trials. 1

    FDA approved for weight management.

    Prescription; online clinics prescribe after a visit. Online clinics from $149/mo (Alloy).11

    Online clinic
  • Tirzepatide (Zepbound)FDA approved

    A weekly shot, same idea, larger average loss in trials.

    FDA approved for weight management.

    Prescription. Online clinics from $299/mo (Alloy).12

    Online clinic
  • Compounded semaglutide or tirzepatideNot FDA approved; pharmacy-made

    Pharmacy-made copies sold by online clinics, often cheaper. Not checked by the FDA batch by batch.

    Not FDA approved; pharmacy-made.

    Prescription through the clinic. Online clinics from $60/mo (Mochi Health).13

  • RetatrutideNot approved; still in trials

    A newer three-hormone shot, still in trials. Sold online only from research-use shops.

    Not approved; in trials.

    We do not link to them.

    Prices at 10 shops

Every option, side by side

4 options, each with its FDA status and how you get it.

OptionFDA statusHow you get it
Semaglutide (Wegovy)A weekly shot that cuts appetite; about 15 % body weight lost on average in trials. 1 FDA approvedFDA approved for weight management. Prescription; online clinics prescribe after a visit.
Tirzepatide (Zepbound)A weekly shot, same idea, larger average loss in trials. FDA approvedFDA approved for weight management. Prescription.
Compounded semaglutide or tirzepatidePharmacy-made copies sold by online clinics, often cheaper. Not checked by the FDA batch by batch. Not FDA approved; pharmacy-madeNot FDA approved; pharmacy-made. Prescription through the clinic.
RetatrutideA newer three-hormone shot, still in trials. Sold online only from research-use shops. Not approved; still in trialsNot approved; in trials. We do not link to them.

Online clinic prices

27 plans at the online clinics we track, cheapest first.

ClinicPlanWhat it isPer monthFDA letterOnline clinic
Mochi HealthCompounded SemaglutideCompounded$60care fee not knownnoneOnline clinic
Ivím HealthMembership and MedicationProgram$65+ $74.99/mo careFDA letter 20 Feb 2026Online clinic
AlloyCompounded SemaglutideCompounded$70+ $99/mo carenoneOnline clinic
Mochi HealthCompounded TirzepatideCompounded$90care fee not knownnoneOnline clinic
AlloyCompounded TirzepatideCompounded$100+ $99/mo carenoneOnline clinic
AlloyCompounded LiraglutideCompounded$115+ $99/mo carenoneOnline clinic
Good Life MedsCompounded TirzepatideCompounded$129care fee not knownnoneOnline clinic
AlloyFoundayo PillBrand$149+ $99/mo carenoneOnline clinic
AlloyWegovy PillBrand$149+ $99/mo carenoneOnline clinic
SesameFoundayo PillBrand$149+ $99/mo carenoneOnline clinic
SesameWegovy PenBrand$149+ $99/mo carenoneOnline clinic
SesameWegovy PillBrand$149+ $99/mo carenoneOnline clinic
Fifty 410Compounded Tirzepatide 8-Week ProgramCompounded$149.50all-inFDA letter 20 Feb 2026Online clinic
Zappy HealthCompounded SemaglutideCompounded$159all-inFDA letter 20 Feb 2026Online clinic
Henry MedsGLP-1 Weight ManagementProgram$179care fee not knownnoneOnline clinic
Fifty 410Compounded SemaglutideCompounded$199all-inFDA letter 20 Feb 2026Online clinic
Fifty 410Compounded TirzepatideCompounded$199all-inFDA letter 20 Feb 2026Online clinic
Zappy HealthCompounded TirzepatideCompounded$279all-inFDA letter 20 Feb 2026Online clinic
Direct MedsCompounded SemaglutideCompounded$297all-inFDA letter 9 Sep 2025Online clinic
AlloyZepbound KwikPenBrand$299+ $99/mo carenoneOnline clinic
SesameZepbound KwikPenBrand$299+ $99/mo carenoneOnline clinic
SesameZepbound VialBrand$299+ $99/mo carenoneOnline clinic
Direct MedsCompounded TirzepatideCompounded$399all-inFDA letter 9 Sep 2025Online clinic
FoundWegovy PenBrand$650care fee not knownnoneOnline clinic
FoundOzempic PenBrand, diabetes$1,100care fee not knownnoneOnline clinic
WellMedrOzempic PenBrand, diabetes$1,399care fee not knownnoneOnline clinic
FridaysOzempic PenBrand, diabetes$1,498care fee not knownnoneOnline clinic

Prices are the clinics' published monthly prices on 2 Nov 2026; "from" prices are the lowest shown. A clinic with an FDA warning letter is still listed; the letter is public record.

Compare other goals

Hair lossSkinMuscle growthHealing and jointsSex driveEnergy and aging

Sources

  1. FDA press release, 4 Jun 2021: FDA Approves New Drug Treatment for Chronic Weight Management, First Since 2014 (Wegovy): https://www.fda.gov/news-events/press-announcements/fda-approves-new-drug-treatment-chronic-weight-management-first-2014
  2. Drugs@FDA database (no approved product for retatrutide, PT-141 shop versions, Melanotan II, CJC-1295, ipamorelin or sermorelin on 30 Oct 2026): https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm
  3. Alloy, Wegovy Pill, 2 Nov 2026: https://www.myalloy.com/weight
  4. Alloy, Zepbound KwikPen, 2 Nov 2026: https://www.myalloy.com/weight
  5. Mochi Health, Compounded Semaglutide, 2 Nov 2026: https://joinmochi.com/lp/per-dosage-pricing

Retatrutide

Research-use sellers. We do not link to them. Prices checked 2 Nov 2026.

SellerProductPricePer mgBackground check
Iron AminosRT-3 60MG, 10 Vials600 mg$804.99$1.34/mg4 of 5 checksLab reports: yesNo FDA letter: yesCompany found: yesLegal pages: noFresh prices: yesThis product: COA yes (18)FDA warning letters: noneCompany: Iron Aminos LLC, FLStatus: activeFirst seen: Oct 2026Price checked: 27 Oct 2026
Step One VenturesR-GLP3, 100mg100 mg$140.00$1.40/mg4 of 5 checksLab reports: yesNo FDA letter: yesCompany found: yesLegal pages: noFresh prices: yesThis product: no COAFDA warning letters: noneCompany: Step One Ventures LLC, FLStatus: activeFirst seen: Oct 2026Price checked: 30 Oct 2026
IDUN PeptidesIDN-RT, 30mg (10 Vials)300 mg$559.99$1.87/mg4 of 5 checksLab reports: yesNo FDA letter: yesCompany found: yesLegal pages: noFresh prices: yesThis product: COA yes (10)FDA warning letters: noneCompany: IDUN Peptides LLC, FLStatus: activeFirst seen: Oct 2026Price checked: 27 Oct 2026
Go Alpha Labs (AlphaLabs Peptides)GLP3-RT (60mg) (10 Vials)600 mg$1,518.99$2.53/mg3 of 5 checksLab reports: yesNo FDA letter: yesCompany found: noLegal pages: noFresh prices: yesThis product: COA yes (28)FDA warning letters: noneCompany: not verifiedStatus: activeFirst seen: Oct 2026Price checked: 23 Oct 2026
Southern AminosSA-3R, 100mg100 mg$126.50$1.26/mg3 of 5 checksLab reports: yesNo FDA letter: yesCompany found: noLegal pages: noFresh prices: yesThis product: COA yes (12)FDA warning letters: noneCompany: not verifiedStatus: activeFirst seen: Oct 2026Price checked: 31 Oct 2026
Rocky Mountain CompoundsRMC-3R 30MG KIT (10 Vials)300 mg$395.00$1.32/mg3 of 5 checksLab reports: yesNo FDA letter: yesCompany found: noLegal pages: noFresh prices: yesThis product: COA yes (5)FDA warning letters: noneCompany: not verifiedStatus: activeFirst seen: Oct 2026Price checked: 20 Oct 2026
Lost Coast AminosLCA-R3 - 10mg-60mg60 mg$75.00$1.25/mg3 of 5 checksLab reports: yesNo FDA letter: yesCompany found: noLegal pages: noFresh prices: yesThis product: COA yes (3)FDA warning letters: noneCompany: not verifiedStatus: activeFirst seen: Oct 2026Price checked: 30 Oct 2026
Renova PeptidesGLP RT (10 vial kit), 100mg1000 mg$1,200.00$1.20/mg3 of 5 checksLab reports: yesNo FDA letter: yesCompany found: noLegal pages: noFresh prices: yesThis product: COA yes (3)FDA warning letters: noneCompany: not verifiedStatus: activeFirst seen: Oct 2026Price checked: 27 Oct 2026
Chimera PeptidesRetatrutide, 60mg x 10vials600 mg$359.00$0.60/mg2 of 5 checksLab reports: noNo FDA letter: yesCompany found: noLegal pages: noFresh prices: yesThis product: no COAFDA warning letters: noneCompany: not verifiedStatus: activeFirst seen: Oct 2026Price checked: 18 Oct 2026
Royal Peptides LLCRetatrutide 10-Vial Bulk Kit RT, 100mg Kit (1000mg)1000 mg$1,200.00$1.20/mg1 of 5 checksLab reports: noNo FDA letter: noCompany found: noLegal pages: noFresh prices: yesThis product: no COAFDA warning letters: 1Company: not verifiedStatus: activeFirst seen: Oct 2026Price checked: 19 Oct 2026

Price per mg is price divided by the stated amount; blends have no per-mg price.

Checks are facts we hold about the seller, not a safety or quality grade. Checked 2 Nov 2026.

  1. Iron Aminos, RT-3 60MG, 10 Vials, 27 Oct 2026: https://ironaminos.com/product/rt-3-60mg/
  2. Step One Ventures, R-GLP3, 100mg, 30 Oct 2026: https://s1research.net/product/r-glp3/
  3. IDUN Peptides, IDN-RT, 30mg (10 Vials), 27 Oct 2026: https://idunpeptides.com/research-peptides/idn-rt/
  4. Go Alpha Labs (AlphaLabs Peptides), GLP3-RT (60mg) (10 Vials), 23 Oct 2026: https://goalphalabs.com/product/glp3-60mg-wholesale/
  5. Southern Aminos, SA-3R, 100mg, 31 Oct 2026: https://southernaminos.com/product/sa-3r/
  6. Rocky Mountain Compounds, RMC-3R 30MG KIT (10 Vials), 20 Oct 2026: https://rmcompounds.com/product/rmc-3r-30mg-kit-10-vials/
  7. Lost Coast Aminos, LCA-R3 - 10mg-60mg, 30 Oct 2026: https://lostcoastaminos.com/product/lca-r3-10mg-60mg/
  8. Renova Peptides, GLP RT (10 vial kit), 100mg, 27 Oct 2026: https://renovapeptides.net/product/retatrutide/
  9. Chimera Peptides, Retatrutide, 60mg x 10vials, 18 Oct 2026: https://chimera-peptides.com/product/retatrutide/
  10. Royal Peptides LLC, Retatrutide 10-Vial Bulk Kit RT, 100mg Kit (1000mg), 19 Oct 2026: https://royal-peptides.com/shop/buy-retatrutide-online-usa/